期刊論文著作
Toxic insult & Diabetes Mellitus
Lee, K. I., Su, C. C., Hung, D. Z., Lin, C. T., Lu, T. H., Liu, S. H., *Huang, C. F. Etoposide induces pancreatic b-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicology In Vitro. 2016; (R1-revised).
Yang, T. Y., Yen, C. C., Lee, K. I., Su, C. C., Yang, C. Y., Wu, C. C., Hsieh, S. S., Ueng, K. C., *Huang, C. F. Molybdenum induces pancreatic b-cell dysfunction and apoptosis via interdependent of JNK and AMPK activation-regulated mitochondria-dependent and ER stress-triggered pathways. Toxicol. Appl. Pharmacol. 2016; 294(3): 54-64.
Huang, C. F., Yao, C.Y., Chan, D.C., Wang, C.C., Huang, K.H., Yang, R.S., Tsai, K.S., and Liu, S. H. Arsenic Exposure and Glucose Intolerance/Insulin Resistance in Female Mice with Estrogen Deficiency. Environ. Health Perspect. 2015; 123(11): 1138-44.
Chang, K. C., Hsu, C. C., Liu, S. H., Su, C. C., Yen, C. C., Lee, M. J., Chen, K. L., Ho, T. J., Hung, D. Z., Wu, C. C., Lu, T. H., Su, Y. C., Chen, Y. W., and *Huang, C. F. Cadmium induces apoptosis in pancreatic b-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. PLoS One 2016; 8(2): e54374-e54385.
Chen, K. L., Liu, S. H., Su, C. C., Yen, C. C., Yang, C. Y., Lee, K. I., Tang, F. C., Chen, Y. W., Lu, T. H., Su, Y. C., and *Huang, C. F. Mercuric compounds induced pancreatic islets dysfunction and apoptosis in vivo. Int. J. Mol. Sci. 2012; 13(10):12349-12366.
Wu, H. C., Yang, C. Y., Hung, D. Z., Su, C. C., Chen, K. L., Yen, C. C., Ho, T. J., Su, Y. C., Huang, C. F., Chen, C., H., Tsai, L. M., and Chen, Y. W. Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic b-cell death. Toxicology. 2011; 289:103-111.
Huang, C. F., Chen, Y. W., Yang, C. Y., Tsai, K. S., Yang, R. S., and Liu, S. H. Arsenic and Diabetes: Current Perspectives. Kaohsiung Journal of Medical Sciences. 2011; 27:402-410. (Review article).
Liu, T. H., Su, C. C., Chen, Y. W., Yang, C. Y., Wu, C. C., Hung, D. Z., Chen, C. H., Cheng, P. W., Liu, S. H., and *Huang, C. F. Arsenic induces pancreatic b-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. Toxicol. Lett. 2011; 201: 15-26.
Chen, Y. W., Huang, C. F. (Equal first author), Yang, C. Y., Yen, C.C., Tsai, K. S., and Liu. S. H. Inorganic mercury causes pancreatic beta-cell death via the oxidative stress-induced apoptotic and necrotic pathways. Toxicol. Appl. Pharmacol. 2010; 243: 323-331.
Chen, Y. W., Yang, C. Y., Huang, C. F., Hung, D. Z., Leung, Y. M., and Liu, S. H. Heavy metals and islet function and diabetes development. Islets 2009; 1(3): 1-8.
Yen, C. C., Lu, F. J., Huang, C. F., Chen WK, Liu SH, Lin-Shiau SY. (2007). The Diabetogenic Effects of the Combination of Humic acid and Arsenic: In Vitro and In Vivo Studies. Toxicol. Lett. 172: 91-105.
Chen YW, Huang CF (Equal first author), Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH. (2006) Methylmercury induces pancreatic beta-cell apoptosis and dysfunction. Chem. Res. Toxicol. 19: 1080-1085.
Chen YW, Huang CF (Equal first author), Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH. (2006) The Role of Phosphoinositide 3-Kinase/Akt Signaling in Low-Dose Mercury-Induced Mouse Pancreatic {beta}-Cell Dysfunction In Vitro and In Vivo. Diabetes 55: 1614-1624.
Toxic insult & Neurotoxicity
Chen, C. H., Chen, S. J., Su, C. C., Yen, C. C., Tseng, T. J., Jinn, T. R., Tang, F. C., Chen, K. L., Su, Y. C., Lee, K. I., Hung, D. Z., and *Huang, C. F. Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals. Toxicology. 2013; 303(1): 72-82.
Huang, C. F., Liu, S. H., and Lin-Shiau, S. Y. Pyrrolidine dithiocarbamate augments Hg2+-mediated induction of macrophage cell death via oxidative stress-induced apoptosis and necrosis signaling pathways. Toxicol. Lett. 2012; 214:33-45.
Huang, C. F., Hsu, C. J., Liu, S. H., and Lin-Shiau, S. Y. Exposure to low-dose of cinnabar (a naturally occurring mercuric sulfide (HgS)) caused neurotoxicological effects in offspring mice. J. Biomed. Biotechnol. 2012; 2012:254582-254593.
Lu, T. H., Hsieh, S. Y., Yen, C. C., Wu, H. C., Chen, K. L., Hung D. Z., Chen, C. H., Wu, C. C., Su, Y. C., Chen, Y. W., Liu, S. H., and *Huang, C. F. Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury. Toxicol. Lett. 2011; 204:71-80.
Yen, C. C., Ho, T. J., Wu, C. C., Chang, C. F., Su, C. C., Chen, Y. W., Jinn, T. R., Lu, T. H., Cheng, P. W., Su, Y. C., Lu, S. H., and *Huang, C. F. Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway. Arch. Toxicol. 2011; 85:565-575.
Huang, C. F., Liu, S. H., Hsu, C. J., and Lin-Shiau, S. Y. Neurotoxicological effects of low-dose methylmercury and mercuric chloride in developing offspring mice. Toxicol. Lett. 2011; 201: 196-204.
Huang, C. F., Hsu, C. J., Lin, S. H., Lin-Shiau, S. Y. Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: oxidative stress and down-regulated Na+/K+-ATPase involved. Toxicol. Lett. 2008; 176:188-197.
Huang, C. F., Hsu, C. J., Lin, S. H., Lin-Shiau, S. Y. Ototoxicity induced by cinnabar (a naturally occurring HgS) in mice through oxidative stress and down-regulated Na+/K+-ATPase activities. NeuroToxicology 2008; 29:386-396.
Huang, C. F., Liu, S. H., Lin-Shiau, S. Y. Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice. Toxicol. Appl. Pharmacol. 2007; 224: 192-201.
Traditional Chinese Medicine or New Drug Development & Diseases
Hus, F. L., Huang, C.F. (Equal first author), Chen, Y. W., Yen, Y. P., Wu, C. T., Uang, R. S., Yang, R. S., and Liu, S. H. Antidiabetic Effects of Pterosin A, a Small-Molecular-Weight Natural Product, on Diabetic Mouse Models. Diabetes 2013; 62 (2): 628-638
Tsai, C. F., Hsu, Y. W., Ting, H. C., Huang, C. H., and Yen, C. C. The in vivo antioxidant and antifibrotic properties of green tea (Camellia sinensis, Theaceae). Food Chem. 2013; 136(3-4):1337-1344.
Hsu, Y. W., Tsai, C. F., Chen, W. K., Huang, C. F., and Yne, C. C. A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice. Food Chem.Toxicol. 2011; 49:2624-2630.
Huang, C. F., Yang, R. S., Liu, S. H., Hsieh, P. C., and Lin-Shiau, S. Y. Evidence for Improved Neuropharmacological Efficacy and Decreased Neurotoxicity by Traditional Processing of Rhizoma Arisaematis in Mice. Am. J. Chin. Med. 2011; 39:981-998.
Huang, C. F., Chen, Y. W., Yang, C. Y., Lin, Y. Y., Way, T. D., Chiang, W. C., and Liu, S. H. Extract of Lotus Leaf (Nelumbo nucifera) and Its Active Constituent Catechin with Insulin Secretagogue Activity. J. Agric. Food Chem. 2011; 59:1087-1094.
Leu, Y. L., Chen, Y. W., Yang, C. Y., Huang, C. F., Lin, G. H., Tsai, K. S., Yang, R. S., and Liu, S. H. Extract isolated from Angelica hirsutiflora with insulin secretagogue activity. J. Ethnopharmacol. 2009; 123(2):208-12.
Other (Anti-cancer, Anti-infection, other…ect.)
Su, C. C., Liu, S. H., Lee, K. I., Huang, K. T., Lu, T. H., Fang, K. M., Wu, C. C., Yen, C. C., Lai, C. H., Su, Y. C., *Huang, C. F. Cantharidin induces apoptosis through the calcium/PKC-regulated endoplasmic reticulum stress pathway in human bladder cancer cells. Am. J. Chin. Med. 2015; 43(3): 581-600.
Hung, D. Z., Lin, J. H., Mo, J. F., Huang, C. F., Liau, M. Y. Rapid diagnosis of Naja atra snakebites. Clin. Toxicol. (Phila). 2014; 52(3): 187-91.
Yen, Y. P., Tsai, K. S., Chen, Y. W, Huang, C. F., Yang, R. S., and Liu, S. H. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Arch. Toxicol. 2012; 86:923-933.
Hsieh, S. K., Tzen, T. C., Wu, T. Y., Chen, Y. J., Yang, W. H., Huang, C. F., Hsieh, F. C., and Jinn, T. R. Functional Expression and Characterization of Dipeptidyl peptidase IV from the Black-Bellied Hornet Vespa basalis in Sf21 Insect Cells. Biosci. Biotechnol. Biochem. 2011; 75:2371-2375.
Yen, Y. P., Tsai, K. S., Chen, Y. W., Huang, C. F., Yang, R. S., and Liu, S. H. Arsenic Inhibits Myogenic Differentiation and Muscle Regeneration. Environ. Health Perspect. 2010; 118:949-956.
Tang, C. H., Chiu, Y. C., Huang, C. F., Chen, Y. W., and Chen, P. C. Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress. Toxicol. Appl. Pharmacol. 2009; 224: 192-201.
Yang, R. S., Tzeng, H. P., Ho, F. M., Chuang, C. C., Chen, B. L., Huang, C.F., Chen, Y. W., Chen, R. M., Liu, S. H. Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. Acta biomaterialia. 2009; 5:3258-64.
Yen, C. C., Huang, C. F., Lee, W. J., Hsu, M. J., Liu, S. H., Lin-Shiau, S. Y. Studies on mercurial sulfide, a component of cinnabar, a Chinese herbal medicine, on celluar functions in mouse lung and fibroblasts. Toxicol. Environ. Chem. 2007; 90:181-201.
